Poison Prevention for Toddler | Poison Prevention for Seniors | Medicines

Drugs for Dementia Treatment Options and Risks

dementia patient and caregiver in retirement home

The Bottom Line

A decline in cognitive function can occur with aging and, if it interferes with daily activities, it might be diagnosed as dementia. Several drugs can produce small improvements in dementia symptoms. Adverse effects of these drugs occur frequently, and evaluation in a healthcare facility is often necessary if a person takes too much.

senior woman holding various dementia medications

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The Full Story

Cognitive function refers to a person's ability to learn, remember, and reason. Many people experience some loss of cognitive function with aging. Dementia is the impairment of cognitive functioning severe enough to disrupt daily life and activities. The examples below illustrate some of the ways in which dementia differs from typical age-related changes:

*Alzheimer's or other dementias*	*Typical age-related changes*
Memory loss that disrupts daily life – forgetting recently learned information or important dates, asking for the same information over and over, needing frequent reminders for things that one used to handle routinely.	Sometimes forgetting names or appointments, but remembering them later.
Difficulty in planning or solving problems – can have trouble following a familiar recipe, keeping track of bills, counting change, concentrating.	Making occasional errors when balancing a checkbook.
Difficulty completing familiar tasks – trouble driving to a familiar location, managing a budget, remembering rules of a favorite game.	Occasionally needing help to use a microwave oven or functions on a cell phone.
Confusion about time or place – losing track of dates, seasons, passage of time, one's location.	Being confused about the day of the week, but figuring it out later.
Trouble with words – difficulty participating in conversation or finding the right words.	Sometimes having trouble finding the right word.
Poor judgment – spending money unwisely, less attention to grooming and staying clean.	Making a bad decision once in a while.
Withdrawal from normal activities – avoiding social events, hobbies, sports, and other activities due to loss of cognitive functions such as conversational ability and memory of how to do things.	Sometimes feeling the need to escape work, family, and social obligations.

The most common cause of dementia is Alzheimer's disease (AD), but dementia can occur also with Parkinson's disease (PD) and some other neurologic disorders. Currently, one in 10 Americans aged 65 years and older has Alzheimer's dementia, and people aged 75 years and older are at greatest risk. The symptoms of AD are associated with damage to neurons (nerve cells) in the brain that make acetylcholine (ACh), a neurotransmitter. These neurons are plentiful in areas of the brain associated with thinking and memory. When they are damaged, ACh levels fall and the cognitive function of those areas is reduced.

What Are the Treatment Options?

Medications to help curb the symptoms of AD first appeared 25 years ago. Tacrine (Cognex) was the first drug approved for dementia treatment. Tacrine acted by inhibiting the enzyme acetylcholinesterase (AChE), which would normally break down ACh. This preserves ACh levels in the brain and results in better cognitive function. Tacrine is now off the market, but three newer AChE inhibitors are available: donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne). A fourth drug, memantine (Namenda), acts in a different way to reduce dementia symptoms. Memantine blocks a receptor in the brain (NMDA receptor) to interfere with the neurotransmitter glutamate. It is thought that over-excitation by glutamate might contribute to the death of neurons in AD.

All four of these medications for dementia are available as generics. The three AChE inhibitors are about equally effective in treating mild to moderate Alzheimer's disease. They produce small but measurable improvements in dementia symptoms, but do not stop or reverse the disease. They have also been used to treat cognitive impairment in Parkinson's disease (PD), but can occasionally cause worsening of PD symptoms such as tremor. Rivastigmine is the only AChE inhibitor approved to treat PD dementia.

Memantine has been studied in patients with moderate to severe dementia and it has modest beneficial effects. There are no scientific studies that compare the effectiveness of memantine with the AChE inhibitors, so we don't know if one category of drugs works better than the other. Increasingly, some patients are taking an AChE inhibitor along with memantine. Research so far has not shown a clear benefit for taking a combination of AD drugs. The following table compares important features of the four individual AD medications, as well as a medication containing both memantine and donepezil.

Current Medications for Dementia
Generic name	Forms available	Category	Notes
Tacrine	N/A	AChE inhibitor	Off the market
Donepezil	Oral tablets	AChE inhibitor	Most commonly prescribed AD drug; lowest risk for side effects of the AChE inhibitors
Rivastigmine	Oral capsules, transdermal patch	AChE inhibitor	Patch causes fewer GI side effects than the oral capsules
Galantamine	Oral tablets, liquid, extended-release capsules	AChE inhibitor	Derived from daffodil bulbs
Memantine	Oral tablets, liquid, extended-release capsules	NMDA receptor blocker	Fewer adverse effects than with AChE inhibitors
Memantine/donepezil (Namzaric)	Extended-release capsules	NMDA receptor blocker/AChE inhibitor	No evidence for consistent benefit of combination capsule, and not available as a generic

Does Treatment Have a Downside?

AChE inhibitors can cause gastrointestinal (GI) effects such as nausea, vomiting, and diarrhea – especially when the medication is first started or the dosage is increased. Taking with food can lessen the GI effects. The patch form of rivastigmine causes fewer GI side effects than the corresponding oral capsules. Slowed heart rate, faintness, falls, and hip fractures might occur less commonly when AChE inhibitors are taken. Memantine tends to have fewer side effects than the AChE inhibitors. Side effects reported for memantine include dizziness, confusion, agitation, insomnia, and hallucinations. When memantine is taken together with an AChE inhibitor drug, GI side effects of the AChE inhibitor seem to occur less frequently.

The risks for adverse effects are increased if someone takes too much of an anti-dementia drug. The two patient groups most often affected are toddlers who take the medication unintentionally and people over 70 years of age who unintentionally take too much of their own medication. Children often get the medications from an adult's purse or open medication container. Dementia patients might take extra medicine if they don't recall already having taken their dose. The most common symptoms resulting from unintentional overdoses are vomiting, diarrhea, and drowsiness. About half of the overdoses reported to Poison Control are referred to an emergency room because of the risk for more serious symptoms such as lowered heart rate and mental changes that can last for several days.

When it comes to avoiding toxicity from anti-dementia medicines, the best approach is prevention. Drugs should be stored in child-resistant containers, and small children must be closely supervised when visiting grandparents and others who might have inadequately "child-proofed" their homes. Daily pill organizers are handy, but they are not child-resistant. AD patients sometimes need help keeping track of medicines, so make sure that someone is available to assist them if necessary.

If you have questions about an adverse reaction or possible overdose of one of the drugs for dementia, immediately check the webPOISONCONTROL^® online tool or call Poison Control at 1-800-222-1222 for help 24 hours a day, every day.

Leslie A. McCament-Mann, PhD, RPh
Clinical Toxicologist